CARCINOGENESIS. TERATOGENESIS AND MUTAGENESIS 2006 Vol.18 No.1 P.26-28
Study on rats Arbidol Teratology
Monday Ping Chen Qi Chen Si-yan YAO
Abstract : Background and Purpose : Arbidol hydrochloride (A hydrochloride idol out. Ar)
for the prevention and treatment of influenza drug, in order to ensure the safety of clinical drug. observe the teratogenic
effect on rat embryos and toxicity. Materials and Methods : 80 pregnant rats were divided into 5 groups. control group,
Ar 100,330. 1000 mg (kg · d) and sodium salicylate positive drug dose group, 16 rats each. pregnant rats in each group
were disposed in a row mice, late pregnancy anatomy. Results : Ar high dose of 1000 mg (kg d) of slower growth in
pregnant rats weight, body weight during pregnancy to reduce the net value. the rate of live births decreased fetal weight,
length and tail length decreased fetal ossification slow rate increase The differences were statistically significant compared
with the control group (P <0.05, P <0.01); But no fetal appearance visceral and skeletal deformities. Ar and low dose
[100mg/ (kg · d) and 330 mg (kg · d)] of no significant impact on pregnancy and fetal rats.
Conclusion : 330 mg (kg · d)
for the safe dose of pregnant rats, 1000 mg (kg · d) toxicity in pregnant rats caused a degree of embryos Red role But no Teratology.
Teratogenicity of Arbidol Hydrochloride in Rats
China drug magazine 2006 14 Full text not available at this time
Safety pharmacology Arbidol hydrochloride - Safety evaluation of arbidol in animals
CHEN Qi, Yi-ping, Chen Si-yan, YANG
Arbidol Objective : To evaluate the effects on the central nervous system, cardiovascular
system and respiratory effects. Methods : Observation ig given Arbidol hydrochloride (10,50 and 250 mg · kg-1) in
mice generally, loss of righting reflex, spontaneous activity, sensory and memory, sleep-induced; Observation ig
given Arbidol hydrochloride (10, 30 and 90 mg · kg-1) changes in the temperature of rabbits; Observation ig given
Arbidol hydrochloride (20 and 80 mg · kg-1) in anesthetized dogs breathing frequency and amplitude. systolic and
diastolic blood pressure, heart rate and rhythm, a QRS ECG T-wave, PR interval, and ST segment affected.
Results : ig mice Arbidol hydrochloride (250 mg kg), a synergistic effect of sodium
pentobarbital-induced sleep. The remaining parameters were not significantly affected.
CONCLUSION : Arbidol effects on the central nervous system. no effect on the cardiovascular and respiratory systems.
China pharmacology communications, 10, 2004
Arbidol hydrochloride Pharmacodynamic study of anti-influenza virus infection
Jinyuqin, non-Sun, Shuqin, Shu-qin LIU Zhi-yi, Liu Jianwei, Yan Qi
Objective : Determination of the concentration of dog plasma Api Dole.
Objective To investigate the effects of the anti-influenza virus Arbidol role. Methods vivo,
in vitro model of influenza virus. Application for a certain concentration of hydrochloric acid in vitro Arbidol role
in the influenza A virus subtype H1N1 infection of host cells. To investigate the use of CPE and the cell viability was
measured by MTT assay; hydrochloric acid in vivo application for the treatment of influenza virus infection in mice Arbidol
model Index changes in the lung. Arbidol hydrochloride results in vivo, In vitro anti-influenza viruses have the same effect.
Conclusion Arbidol hydrochloride is a good anti-virus drugs.
China Pharmaceutical University Journal, 2004 01 period
RP hydrochloride Api Dole Dog plasma concentration Determination of Arbidol in Dog Plasma by RP
Meng, Sun Jianguo, Wang Guangji, Jiang Xi Ling, Hao Li
Objective : Determination of the concentration of dog plasma Api Dole.
Methods : Plasma samples were stable internal standard. saturated sodium carbonate
alkali after ether extraction and sample enrichment; The mobile phase was methanol-water (72 : 28). 5 L of sodium
dodecyl sulfate aqueous phase by adding 1.32% triethylamine. phosphate at pH = 3.0; Hanbang Technology Lichrospher
C8 column (5 µm. 250 mm × 4.6 mm ID. ), the detection wavelength of 318 nm. R.F. rate of 1.0. Determination of a
single oral dose of Api Dole dogs 100mg tablets of the plasma concentration-time curve. Results : 5th standard curve
was linear in the range of 000 ml (r = 0.9994) ;25, 250. 1 GHRP average absolute recoveries were 92.1%,94.1% 000 ml.
104.3%, 112.7%; 25, 250, 1 000. 8.0%, 8.0%, 8.1%, 1.6%; 25 precision for five days deviation. 250, 1% respectively 16.5%,
7.2%, 8.0% GHRP 000 ml day. 1.3% with the method for analyzing biological samples.
Conclusion : The method of sample
preparation process is simple, reproducible, suitable for the determination of large quantities of samples for Api Dole dogs
plasma concentration achieved good results.
NII - SCIENTIFIC RESEARCH INSTITUTE microbiology MO RF English (machine translation .html)
Experimental data on the effectiveness Of arbidola with respect to the agent of atypical pneumonia (SARS) in vivo and in vitro
Hamites R.A., Schuster A.M., Loginova S.ya., Borisevich S.V. Of faldina V.N., Koval'chuk A.V.
The search for the effective medical means of preventive maintenance and treatment
of "atypical pneumonia" (SARS) is vital problem. It is at present known that the inhibiting action on the culture of
the cells of virus SARS render interferons (a, b), and also ribavirin in the high concentrations (500-5000 g/ml).
Purpose of a study. To study in vitro and in vivo the effectiveness of aribidola (PRIVATELY
HELD COMPANY Of "masterlek") and its derived - mezilata arbidola ((NPF "SINBIAS FARMA", g.Donetsk, the Ukraine,
the supplier PRIVATELY HELD COMPANY Of "masterlek") with respect to agent SARS.
NII - SCIENTIFIC RESEARCH INSTITUTE microbiology English (machine translation .html)
Russian virusologists and Syrian small hamsters
Glushkov RG, Gus'kova TA, Krylova LIu, Nikolaeva IS.
The flash of heavy sharp respiratory syndrome (SARS), the very same
SARS, that was begun during November 2002 in South China, did not pass without leaving a trace.
Epidemic was extended in Vietnam, Singapore, Thailand, China (Hong Kong), Canada, Taiwan and
USA. One case of atypical pneumonia was registered, also, in Russia, in Amur region. Physicians
await new communications about this fatal illness.
NII - SCIENTIFIC RESEARCH INSTITUTE microbiology English (machine translation .html)
REPORT about the experimental study of embryotoxicity and influence on the reproductive function of the substance of the preparation of "arbidol"
The preparation of arbidol; is the antiviral and
immunostimulating means, it renders the immunomodulating and anti-influenza
action, specifically suppresses the viruses of influenza A and B prevents
contact and penetration of viruses into the cell, suppressing the confluence of
the lipid shell of virus with the cellular membranes. It possesses the
interferonindutsiruyushchim action, it stimulates the humoral and cellular
reactions of immunity, the phagocytic function of macrophages, increases the
stability of organism to the virus infections. Is reduced the frequency of the
development of the complications, connected with the virus infection, and also
the aggravations of chronic bacterial diseases.
D.I. Ivanovsky Research Institute of Virology RAMS, Moscow, Russia; Royal Melbourne Institute of Technology, Melbourne, Australia - Full text not available at this time
Experimental study of arbidol antiinfluenza activity in mice
Background: Arbidol is a new Russian preparation with specific antiviral and immune stimulation
activity. It was elaborated in the Center for Chemical and Medical Preparation of the Allrussian Research
Chemical-Pharmaceutical Institute, Moscow.
Methods: To estimate protective dose of Arbidol for mice infected by A/Aichi/2/68
(H3N2) Influenza virus (adapted for them) according to its influence on mortality. There were 4 groups of
mice in experiment. In the group of positive control (no medicine, only virus) were 8 mice; in the group of
negative control (60 mg/kg of Arbidol, no virus) - 16 mice; two experimental groups with concentrations of
Arbidol - 30 mg/kg and 60 mg/kg - by 16 mice in each one. Arbidol was inoculated intragastrically by gavage 5 times.
Results: Mortality in experimental group with concentration of Arbidol 60 mg/kg was equaled to
31.3%, when it was 75% in the group of Arbidol 30 mg/kg. And it was 87.5% in the group of positive control. All mice
were alive in the group of negative control. Accordingly to this results therapeutically dose of Arbidol in this investigation was 60 mg/kg.
Conclusion: Results of this study are in agreement with previously received clinical
data of the therapeutical efficacy of Arbidol against Influenza.
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):482-8. - Full text not available at this time
Immunopharmacological analysis of secondary postradiation immunodeficiency
Ivanov AA, Deshevoi IuB, Karpova NA, Lebedev VG, Leonenko IV, Stavrakova NM, Tazulakhova EB, Ulanova AM, Khaustova LI, Shal'nova GA
A model for secondary postradiation immunodeficiency of mice
has been used to compare immunocorrective activities of some new immunomodulators
(arbidol, cagocel, myelopid, proleukinferon and fragmine) administered at late times
(2-3 months) after exposure to a nonlethal radiation dose (4.0 Gy). The highest
immunocorrective effect has been shown with fragmine and proleukinferon.
PMID: 7951873 [PubMed - indexed for MEDLINE
