Health UA 10 4 2006 English (professional translation .pdf)
Specific Molecular-Biological Actions of the Antiviral Drug Arbidol
Arbidol is an antiviral drug which is effective against Group A and B influenza strains. The molecular-biological
action which distinguishes Arbidol from other drugs is its ability to inhibit viral reproduction in the early stages; the drug acts by changing
the regulation of cell metabolism. Arbidol differs from rimantadine in the molecular mechanism of its antiviral action.
Original Russian Document .pdf
Volprosy Virusologii Volume: 51 Issue: 5 2006 Pages 4-7 English translation not available at this time
Antiviral Etiotropic efficacy against Influenza A subtype H5N1
N.A. Leneva, A. M. Shuster
The paper analyzes data of an experimental study of the efficacy of antiviral agents (amantadine,
rementadine, ozeltamivir, zanamivir, arbidol, ribavirin) in the cultured cells and on a model of murine influenza pneumonia
against influenza A viruses subtype H5N1. It also gives data on their use in the treatment of human beings during avian
influenza outbreak. The mechanism of action of the agents, pharmacokinetics, adverse reactions, and their potential
resistance are considered.
Original Russian Document .pdf
Journal of Pharmaceutical and Biomedical Analysis Vol. 43, No. 1, pages 371-375 (2007) English translation not available at this time
Determination of arbidol in human plasma by LC-ESI-MS
Liu, X., Huang, Y.W., Li, J., Li, X.B., Bi, K.S., Chen, X.H.
Abstract: A sensitive, specific and accurate method for determination of arbidol in human
plasma was developed. Arbidol and internal standard were extracted from plasma samples by liquid-liquid extraction
with diethyl ether. The chromatographic separation was accomplished on a Shiseido C"1"8 3@mm analytical column
(100mmx2.0mm i.d.) at a flow rate of 0.3mL/min isocratically. Detection was performed on a single quadrupole mass
spectrometer by selected ion monitoring (SIM) mode via electrospray ionization (ESI) source. The method had a
chromatographic run time of 6min and a good linear relationship over the range 1-1000ng/mL. The limit of quantitation
for arbidol in plasma was 1ng/mL. The intra-day and inter-day precision (R.S.D.%) was lower than 7% and accuracy
ranged from 95 to 105%. The proposed method enables unambiguous identification and quantification of arbidol in vivo
and has been successfully applied to study the pharmacokinetics of arbidol in healthy male Chinese volunteers.